Publications

Researchers describe quantitative trait loci associated with differential splicing in neuroblastoma to identify genes with previously unknown functions within the splicing pathway and to define de novo intronic splicing motifs that influence splicing from hundreds of bases away.

Researchers develop a novel computational algorithm called MethylMix to identify differentially methylated genes that are also predictive of transcription.

Researchers identify seasonal testosterone-sensitive transcriptomes of major song-related brain regions, HVC and RA, and find the seasonal gene networks related to neuronal differentiation only in the HVC.

Researchers discuss the critical importance of acquiring and utilizing high sequencing depth in profiling clinical tumor samples and presents a very useful platform for implementing routine sequencing in a cancer care institution.

Whole exome sequencing on adenomas from three mouse models of non-small-cell lung cancer, induced by explosure to carcinogens or genetic activation of Kras, aims to address questions regarding factors that induce driver mutations and shape mutation selection during tumorigenesis.

Researchers develope MethylMix, an algorithm implemented in R to identify disease specific hyper and hypomethylated genes.

Organoid models were established from normal and neoplastic murine and human pancreas tissues. Orthotopically transplanted neoplastic organoids recapitulate the full spectrum of tumor development by forming early-grade neoplasms that progress to locally invasive and metastatic carcinomas.

Researchers introduce Thiasporine A, and report on the cytotoxicity against the non-small-cell lung cancer cell line H2122.

In this study, researchers propose a novel prior-incorporated sparse regression model in which the choice of informative predictor sets is carried out by knowledge-driven priors (gene sets) in a stepwise fashion.

To search for new therapeutic target proteins in high-grade serous ovarian carcinoma, researchers performed an in vivo shRNA screen using an established human HGSOC cell line growing either subcutaneously or intraperitoneally in immunocompromised mice.