Publications

The transcription factor SOX4 plays a critical role in prostate cancer and may be a potential target for combinatorial therapies.

Review on potential applications of the pancreatic ductal organoids(PDA), three-dimensional culture systems and organoid-based xenografts as new preclinical models for PDA.

Researchers highlight Myc in inducing glutamine synthesis and suggest a molecular connection between DNA demethylation and glutamine metabolism in Myc-driven cancers.

This study demonstrates overexpression of YAP stimulates cell proliferation whereas knocking down YAP or treating cells with Verteporfin inhibited cell proliferation. This study provides potential approaches to select patients likely to benefit from Verteporfin.

Researchers use the Cancer Therapeutics Response Portal to analyze mechanism of action for small molecules based on changes in gene expression.

Researchers screened a panel of non-small cell lung cancer cell lines for chemical sensitivity and identified SW044248, a topoisomerase I inhibitor.

Researchers demonstrate that SWI/SNF-mutant cancer cells are primarily dependent on a non-catalytic role of EZH2 in the stabilization of the PRC2 complex, and that they are only partially dependent on EZH2 histone methyltransferase activity.

Epigenetic regulator RNF2 has a dual role in tumorigenesis and metastasis of melanomas.

Investigators used large-scale genomics to separate driver and passenger mutations and learn more about the functionality of driver mutations.