Publications
Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
A literature review revealed that there are many mechanisms of drug resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small-cell cell lung cancer.
This review discusses the pros, cons and recent advances of organoids as tumor models.
Researchers illustrate a novel way of using isotopically enhanced two-dimensional NMR spectroscopy to interrogate reaction mechanisms as they occur.
The authors incorporated existing knowledge of gene interactions to generate more accurate statistical predictions of gene interaction networks.
An shRNA screen identified the only lung cancer cell line in the panel to be sensitive to knockdown of MAP2K1 and thus sensitive to MEK1 inhibition.
Expression of cytochrome P450 makes cell lines sensitive to oxalamides and benzothiazoles.
These results implicate PDE3A modulators as candidate cancer therapeutic agents and demonstrate the power of predictive chemogenomics in small-molecule discovery.
Researchers describe methodology for detailed studies of human Neural crest cells (NCC), and clarifies roles for retinoids and bone morphogenetic proteins in the differentiation of human pluripotent stem cells to trunk NCC and to sympathoadrenal lineages.
The authors use a gain-of-function screening platform to clone and functionally assess mutations that occur at low frequency in pancreatic cancer
Investigators develop an algorithm to statistically analyze off-target effects of RNAi and CRISPR screens.