Publications
Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
Computational analysis of an RNAi screen in non-small cell lung cancer cell lines reveals potential targets.
Researchers demonstrate the diversity of tumor cellular response to ionizing radiation and establish multiple lines of evidence to identify new genetic features regulating cellular response after DNA damage.
A new version of the ARACNe algorithm enhances computational performance and enables the construction of complex gene regulatory networks from hundreds of gene expression profiles.
This study used whole exome capture sequencing to compare biopsies from the same patient at diagnosis, remission and relapse and revealed that there was significant variability between these stages.
Using genetic lineage tracing, the authors show that Doublecortin-like kinase-1 (Dclk1) labels a rare population of long-lived, quiescent pancreatic cells that are candidates for the origin of pancreatic cancer.
This review aims to summarize these organoid methods in the context of other Pancreatic ductal adenocarcinoma models. While each model system has unique benefits and drawbacks, ultimately, organoids hold special promise for the development of personalized medicine approaches.
Researchers developed an analytical tool that identifies copy number alterations from integrated whole exome sequencing data
Investigators performed genomic characterization of extra-cranial malignant rhabdoid tumors and found dysregulation of neural crest development genes.
Researchers find that deletion of the phosphorylase MTAP makes cancer cell lines vulnerable to PRMT5 inhibition
Researchers highlight pharmacologic inhibition of MAPK signaling produces similar effects to Pten restoration, suggesting that the MAPK pathway contributes to the maintenance of advanced breast cancers harboring Pten loss.