The CTD² Network and Cancer Systems Biology Consortium organized a virtual symposium series titled “Multidisciplinary Approaches to Understand Cancer Treatment Resistance”. Please join us on 11/16, 11/17, 12/2, 12/16, and 12/17. Click here to view the registration website.
Publications
644 Publications Available
Cancer Research
Investigators use a high-throughput assay to identify genomic predictors of radiation sensitivity
Cancer Cell
Researchers document coexpression of EGFR and EGFRvIII in primary human glioblastoma that drives transformation and tumorigenesis in a cell-intrinsic manner and clarify specific oncogenic signaling relationships in glioblastoma.
Clinical Cancer Research
Author comment on Dual blockade of the PI3K/AKT/mTOR(AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergystically inhibits rhabdomyosarcoma...
Cold Spring Harbor Perspective in Medicine
A review on the role of MYCN and other newly identifed drivers in neuroblastoma.
Nature Genetics
A collaborative effort to compare the molecular changes across the original 12 tumor types profiled by The Cancer Genome Atlas.
Journal of the American Chemical Society
Using a newly developed platform to identify the signaling pathway/molecular target of natural products, we identified a family of alkaloid natural products, discoipyrroles A-D (1-4), from Bacillus hunanensis that inhibit the DDR2 signaling pathway.
Cancer Discovery
3q26 is frequently amplified in several cancer types with a common amplified region containing 20 genes. To identify cancer driver genes in this region, we interrogated the function of each of these genes.
PLoS Genet
Cell
The Cancer Therapeutics Response Portal (www.broadinstitute.org/ctrp) was created to identify cancer genotype-compound sensitivity relationships.
Bioinformatics
Researchers introduce the PiHelper, which integrates human drug-target and antibody-target associations from publicly available resources to help meet the needs of researchers in systems pharmacology, perturbation biology and proteomics.