Publications

Researchers introduce a sequential trimming-and-retrieving alignment approach for investigating DNA methylation patterns, which significantly improves the number of mapped reads and covered CpG sites.

Researchers performed genomewide analyses of 293 lower-grade gliomas from adults, incorporating exome sequence, DNA copy number, DNA methylation, messenger RNA expression, microRNA expression, targeted protein expression, and tested for correlation with clinical outcomes.

Investigators determine the molecular mechanism of the chemotherapeutic agent didemnin B and find a biomarker to predict sensitivity.

This review offers a practical resource to compare and contrast these technologies, guiding the investigator when and where to use this fantastic array of powerful tools.

Researchers report the BAMSurgeon tool for simulating cancer genomes and the results of 248 analyses of three in silico tumors.

Researchers report on  the discovery of a novel, small-molecule modulator of lysosomal acidification derived from diversity-oriented synthesis through high-content screening.

To uncover novel mechanisms of resistance to anti-HER2 therapy in breast cancer, researchers performed a kinase open reading frame screen to identify genes that rescue HER2-amplified breast cancer cells from HER2 inhibition or suppression.

Researchers discuss BRAF inhibitor-resistant melanomas can be actionably classified using protein expression patterns, even without identification of the underlying genetic alteration.

New ways of suppressing KRAS gene expression and of harnessing the immune system to exploit previously unrecognized vulnerabilities in human cancers. 

A review about 3D culture models for cancer research.