Publications

Researchers demonstrate the diversity of tumor cellular response to ionizing radiation and establish multiple lines of evidence to identify new genetic features regulating cellular response after DNA damage.

A new version of the ARACNe algorithm enhances computational performance and enables the construction of complex gene regulatory networks from hundreds of gene expression profiles.

Using genetic lineage tracing, the authors show that Doublecortin-like kinase-1 (Dclk1) labels a rare population of long-lived, quiescent pancreatic cells that are candidates for the origin of pancreatic cancer.

This review aims to summarize these organoid methods in the context of other Pancreatic ductal adenocarcinoma models. While each model system has unique benefits and drawbacks, ultimately, organoids hold special promise for the development of personalized medicine approaches.

Researchers developed an analytical tool that identifies copy number alterations from integrated whole exome sequencing data

Researchers find that deletion of the phosphorylase MTAP makes cancer cell lines vulnerable to PRMT5 inhibition

Researchers highlight pharmacologic inhibition of MAPK signaling produces similar effects to Pten restoration, suggesting that the MAPK pathway contributes to the maintenance of advanced breast cancers harboring Pten loss.

A literature review revealed that there are many mechanisms of drug resistance to EGFR tyrosine kinase inhibitors (TKIs) in non-small-cell cell lung cancer.

This review discusses the pros, cons and recent advances of organoids as tumor models.

Researchers illustrate a novel way of using isotopically enhanced two-dimensional NMR spectroscopy to interrogate reaction mechanisms as they occur.