Publications

A stromal protein signature for breast cancer (BCa) was created using tissue and matched lysates from two breast cancer patient datasets. Protein contents of the stroma were shown to be an extended phenotype not predicted by mRNA expression and could be utilized to subclassify BCa subtypes.

Researchers identified that MDM2/XIAP inhibitors exhibit anticancer activity in vitro and in animal models.

Researchers at UTSW medical center identified nuclear export receptor XPO1 as a druggable target in certain types of KRAS mutant non-small cell lung cancers.

Combination of complimentary genetic and proteomic approaches identify previously unreported regulators of β-catenin, define functional networks required for the survival of β-catenin-active cancers, and provide an experimental strategy that may be applied to define other signaling networks

Investigators identify 19 human Mammary Tumor Associated RNAs that are significantly upregulated which correlate with breast cancer subtype and/or hormone receptor status, indicating potential clinical relevance.

Researchers introduce a novel mechanism regulating von Hippel Lindau (VHL) proteostasis and function, which is significant for identifying new drug targets and developing new therapeutic approaches targeting VHL deficiency in VHL diseases.