Publications

Researchers show that overexpression of protocadherin 7 enhances MAPK signaling by binding to protein phosphatase 2A in lung cancer.  

Expression profiles of 810 cancer lines and their response data to 368 small molecules from the Cancer Therapeutics Research Portal were analyzed to identify pathways with significant gene rewiring or differential gene dependency, between sensitive and non-sensitive lines.

The CTD2  Dashboard is an interactive web interface which compiles conclusions with associated supporting evidence. This open access resource makes the data findable, accessible, interoperable and reusable to both computational and non-computational experts. 

CTD2 Center researchers at UCSF provide insight into how the three sensors of endoplasmic reticulum homeostasis monitor distinct types of stress and highlight the ability of Perturb-seq to dissect complex cellular responses using CRISPRi screens.