Publications

This manuscript presents a method called Evaluation of Dependency DifferentialitY (EDDY), which is a statistical test for differential dependencies of a set of genes between two conditions.

Researchers at Emory disucss their high throughput research platforms and efforts to advance understanding of disease-related biology with its HTS/HCS platforms and chemical tools, in support of  drug discovery.

Investigators used a novel mouse model to study genetic changes in prostate cancer.

Researchers identify ARID1A-mutant cancer cells are dependent on ARID1B for survival, suggesting a potential therapeutic target.

Researchers screen for synthetic lethal interactions with MYC to identify possible routes for therapy.

A review of how a systems biology approach to cancer research can effect therapy development.

The authors performed an image-based screen for genes regulating glioblastoma tumor-initiating cell maintenance and identified the transcription factor, ZFHX4, as a master regulator.

The researchers identified the GRB2-associated binding protein 2 (GAB2) as a recurrently amplified gene that potently transforms immortalized ovarian and fallopian tube secretory epithelial cells. 

Glutathione peroxidase 4 regulates ferroptotic cancer cell death.

Investigators identified molecular players in response and resistance to combination chemotherapy and antiangiogenic drugs.