Publications
Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
Researchers present a new technique for unsupervised clustering that can help determine the optimal number of clusters in a data set called COmbined Mapping of Multiple clUsteriNg ALgorithms (COMMUNAL).
Researchers discuss a novel variant annotator, TransVar, to perform three main functions supporting diverse reference genomes and transcript databases.
Authors discuss using a novel ACME algorithm to identify drug mechanisms of action, molecular markers of response, responsive cancer subtypes and compounds that produce synergistic cell inhibition.
Researchers introduce a technology to unbiasedly select high specificity compound(s) that bind any biomolecule (e.g., proteins, lipids, carbohydrates) presented on the cancer cell surface but not on normal cells.
Researchers identified clinically relevant A-to-I RNA editing events by analyzing the RNA editing profiles of over 6,000 patient samples.
Researchers quantitatively measured the sensitivity of hundreds of cancer cell lines to a panel of small molecules, and created a publicly-available portal to disseminate the results.
This review, we focus on the discovery, structure and function, and therapeutic implication of three of these adaptor oncogenes, CRKL, GAB2, and FRS2.
Homodimers of the p85α regulatory subunit stabilize PTEN and enhance its activity, thereby supressing PI3K activity.
Researchers identify a substantial fraction of human NSCLCs activates an NRF2-dependent transcriptional program that regulates serine and glycine metabolism and is linked to clinical aggressiveness.
Researcher report on an unexpected role for Phosphoenolpyruvate carboxykinase (PEPCK) in promoting cancer cell proliferation in vitro and in vivo by increasing glucose and glutamine utilization toward anabolic metabolism.