How to access multiple datasets

Publications

38 Publications Available
Altered Transcriptome in Pediatric AML Compared with Normal Hematopoiesis
British Journal of Cancer Research
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Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.
Cell Reports
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Predicting Complete Remission of Acute Myeloid Leukemia: Machine Learning Applied to Gene Expression.
Cancer Informatics
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Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia.
Leukemia
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A unique subset of low-risk Wilms tumors is characterized by loss of function of TRIM28 (KAP1), a gene critical in early renal development: A Children's Oncology Group study.
PLoS One
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Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T Cell Receptors in High-risk MYCN-not-amplified Human Neuroblastoma.
Clinical Cancer Research

TARGET study associated RNA signatures of cytotoxic tumor-infiltrating lymphocytes with the presence of activated NK-/T-cells and suggested improved outcomes in newly diagnosed high-risk neuroblastoma patients with MYCN-NA tumor.

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The genetic basis and cell of origin of mixed phenotype acute leukaemia.
Nature
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Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma.
Oncogene

Authors identified transcription factor activating protein 4 (TFAP4) as a critical effector of MYCN amplification in neuroblastoma and showed that silencing TFAP4 inhibits MYCN-amplified neuroblastoma cell growth. 

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Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.
Cancer Discovery

Scientists proposed a framework to investigate the genomic alterations in neuroblastoma subtypes and identified TEAD4, a transcription factor, as a novel target for therapy.

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Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.
Nature

This study by TARGET researchers analyzed DNA changes and sequenced the genomes, exomes, and transcriptomes of 1,699 pediatric leukemia and solid tumors. Out of the 142 genes associated with cancer in these pediatric patients, only 45% matched those found in similar studies of adult cancers.

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