Publications

Researchers discuss a role for SMARCA2 in oncogenesis caused by SMARCA4 loss and identify the ATPase and bromodomain-containing SMARCA2 as a potential therapeutic target in these cancers.

Researchers discuss quantitative solution to overcorrection and guidance for effective designs of deep sequencing platforms that facilitate accurate estimation of variant allele fraction and copy number variation.

The genetically engineeded mouse model system created by the authors produces a disease that recapitulates the progression of pancreatic cancer in human patients and enables the study of the impact of gene perturbation at any stage of pancreas cancer progression.

Researchers describe recent structural and functional studies describing genomic alterations and new regulators of β-catenin that lead to aberrant activation of the WNT/β-catenin pathway.

Researchers use an EGFP-tagged Cas9 protein to image genomic loci and study chromatin dynamics

The authors identify the AKT1 kinase as a major negative regulator of the NR3C1 glucocorticoid receptor protein activity driving glucocorticoid resistance in T cell acute lymphoblastic leukemia (T-ALL). 

This review discusses important therapeutic targets and provides renewed interest in strategies for the early detection and prevention of childhood cancer.

The authors use an elastic-net regression method on the combined genomic data to identify genetic aberrations and their associated cancer genes that are indicators of clinical stage colorectal cancer.

The results suggest JQ1 suppresses MYC expression and MYC-associated transcriptional activity in medulloblastomas, decreasing medulloblastoma cell viability.

Investigators used whole genome sequencing to evaluate the intratumor heterogeneity of one HPV-positive oropharyngeal squamous cell carcinoma.