Publications
Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
This review offers a practical resource to compare and contrast these technologies, guiding the investigator when and where to use this fantastic array of powerful tools.
Researchers report the BAMSurgeon tool for simulating cancer genomes and the results of 248 analyses of three in silico tumors.
Researchers report on the discovery of a novel, small-molecule modulator of lysosomal acidification derived from diversity-oriented synthesis through high-content screening.
To uncover novel mechanisms of resistance to anti-HER2 therapy in breast cancer, researchers performed a kinase open reading frame screen to identify genes that rescue HER2-amplified breast cancer cells from HER2 inhibition or suppression.
Researchers discuss BRAF inhibitor-resistant melanomas can be actionably classified using protein expression patterns, even without identification of the underlying genetic alteration.
New ways of suppressing KRAS gene expression and of harnessing the immune system to exploit previously unrecognized vulnerabilities in human cancers.
A review about 3D culture models for cancer research.
In this reveiw authors discuss how organoid methods have the potential to herald the dawn of a new era in cancer biology investigation.
Researchers used deep whole-exome sequencing to describe the clonal architecture and evolution of 20 pediatric B-acute lymplobastic leukaemias from diagnosis to relapse.
Researchers conducted a large-scale functional genetic study to characterize mechanisms of resistance to ALK inhibition in ALK-dependent lung cancer cells and identified additional members of known of putative resistance drivers.