Publications
Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
In this first comprehensive genomic study of T-lineage acute lymphoblastic leukemia (T-ALL),researchers identified a large number of unrecognized driver mutations and associated altered pathways. These results have significant therapeutic weight in children with T-ALL.
Scientists have developed a cancer dependency map by combining off-target effects of RNAi and genomic characterization information across 501 cancer cell lines. The map facilitates identification and prioritization of therapeutic targets by predicting the genes essential for cell viability.
Plasticity of the cell state is proposed to drive resistance to multiple classes of cancer therapies. CTD2 researchers characterized this therapy-resistant cell state in human cancer cells and identify vulnerability to ferroptosis by inhibition of a lipid peroxidase.
CTD2 researchers at UTSW investigate alterations in oncogene-specific cellular signaling pathways in non-small cell lung cancer. BLC6 was identified as a target for combination therapy and may be potent way to overcome intratumor heterogeneity.