Publications
Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
CTD2 scientists at UT MD Anderson Cancer Center developed a user-friendly bioinformatic resource, The Cancer Proteome Atlas (TCPA). This resource contains the expression levels of key cancer proteins (characterized by reverse-phase protein arrays) from patient tumors and cancer cell lines.
CTD2 comprehensive molecular analysis of TCGA muscle-invasive (metastasis) bladder cases aid in subtyping and may inform optimal treatment options.
Authors performed comprehensive analysis of WT and identified convergence of numerous genetic changes on limited developmental pathways resulting in oncogenesis. Findings suggested that targeting common pathways was better for intervention than targeting individual gene mutations.
Scientists found that overexpression of PRAS40 in lung adenocarcinoma and cutaneous melanoma was associated with poor prognosis. This study describes a novel protein interaction signaling node where PRAS40 can increase NF-κB transcriptional activity through physical association with P65.
Scientists use hydrocarbon peptide stapling to develop cell permeable and stabile peptides capable of blocking RAB25-FIP complex formation. These peptides inhibit RAB25-depenent (pro- and anti-tumorigenic) phenotypes in cancer cells.