In the News

The genetic engineering system, clustered regularly interspaced short palindromic repeats (CRISPR), has conventionally been used to inactivate genes by making targeted double stranded cuts in DNA…

Neuroendocrine specific lung cancers comprise about 10% of non-small cell lung cancer (NSCLC) cases and all small cell lung cancer (SCLC) cases. Studies have previously shown that the…

In a recent publication in Cancer Cell, CTD2 investigators discovered that a known cancer-associated gain-of-function alteration in phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) results…

Acute lymphoblastic leukemia (ALL) is the most prevalent cancer among children and young adults, and standard treatments within this population generally result in favorable outcomes. By contrast…

The tumor suppressor p53 is mutated in over 50% of head and neck squamous cell carcinomas (HNSCC), yet there are currently no available therapies to target it. CTD2 researchers at the Fred…

Humans are diploid organisms, meaning they inherit one set of chromosomes from each parent. One copy of the gene that encodes the DNA binding protein, CCCTC-binding factor (CTCF), is commonly…

Cancers treated with targeted therapies against oncogene dependencies often develop resistance. Upon oncogene suppression, other genes are often able to sustain tumor survival. In a recent Cell…

In a recent report in CancerOpens in a New Tab, Dr. Malcolm Smith and colleagues evaluated the progress in identifying more effective treatments for pediatric cancers…

Dialogue for Reverse Engineering Assessments and Methods, or DREAM, invites the community to propose creative solutions to develop and evaluate complicated systems biology algorithms and…

The Guide to Accessing TARGET Data is a new webpage OCG designed to help data users navigate through the Data Use Certification process, maintain their user accounts, and download TARGET data. It…